Clinical and laboratory findings in sheep experimentally poisoned by Palicourea marcgravii and the use of magnesium chloride with possible therapeutic effect on poisoning

ABSTRACT: This study aimed to examine the efficacy of magnesium chloride therapy in sheep experimentally poisoned by Palicourea marcgravii and describe clinical laboratory findings that may aid early ante mortem diagnosis this poisoning. P. is an important plant within a group 22 species Brazil cause “sudden death.” Its toxic component sodium monofluoroacetate. It was observed time for evolution poisoning longer our compared other studies used same dose sheep. However, all animals were subsequently treated with died. The presented characteristic signs before death addition have not been previously described type poisoning, such as abdominal breathing, coughing, head pressing, nystagmus. first evaluation hematological parameters marcgravii. Leukocytosis neutrophilia, hyperfibrinogenemia, hyperglycemia, associated hypophosphatemia elevated levels serum aspartato aminotransferase (AST), glutamate dehydrogenase (GLDH), urea, creatinine, creatine kinase (CK) lactate (LDH), observed. Additionally, changes noted necropsy, engorged jugular, large vessel congestion, pulmonary edema. Histological examination revealed vacuolar hydropic degeneration distal twisted uriniferous tubules kidneys, similar those reported previous on